Histamine H3 receptor antagonist decreases cue-induced alcohol reinstatement in mice
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- 作者：Saara Nuutinena ; b ; d ; Tiia Mä ; kia ; b ; Stanislav Rozova ; b ; Pia Bä ; ckströ ; mc ; Petri Hyytiä ; c ; Petteri Piepponend ; Pertti Panulaa ; b ; pertti.panula@helsinki.fi" class="auth_mail" title="E-mail the corresponding author
- 关键词：Histamine ; H3 receptor ; Alcohol ; Operant self-administration ; Cue-induced reinstatement ; Microdialysis ; Reward ; Addiction
- 刊名：Neuropharmacology
- 出版年：2016
- 出版时间：July 2016
- 年：2016
- 卷：106
- 期：Complete
- 页码：156-163
- 全文大小：984 K
文摘
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Operant oral alcohol administration paradigm in mice was established in this study.
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Operant responding was reinstated by cues associated with alcohol administration.
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Histamine H3 receptor antagonists inhibited cue-induced reinstatement of alcohol seeking.
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Alcohol did not affect histamine release in nucleus accumbens.
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H3 receptor antagonist increased histamine but not dopamine release in nucleus accumbens.