Bothrops jararaca venoms from south and southeast Brazil have different renal effects. B. jararaca venom (Bjv) from south is more nephrotoxic than from Bjv from southeast. Bjv from south showed characteristics of renal injury on isolated kidney. Bjv from southeast showed a diuretic effect on isolated kidney. Bjv from south showed a higher necrotic profile than Bjv from southeast in MDCK cells.