In vitro evaluation of oestrogenic/androgenic activity of the serum organochlorine pesticide mixtures previously described in a breast cancer case-control study
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- 作者：Javier Rivero ; Octavio P. Luzardo ; octavio.perez@ulpgc.es" class="auth_mail" title="E-mail the corresponding author ; Luis A. Henrí ; quez-Herná ; ndez ; Rubé ; n P. Machí ; n ; José ; Pestano ; Manuel Zumbado ; Luis D. Boada ; Marí ; a Camacho ; Pilar F. Valeró ; n
- 关键词：Endocrine disruption ; DDT ; Cyclodienes ; POPs ; Human breast cancer cells ; Pesticide mixtures
- 刊名：Science of the Total Environment
- 出版年：2015
- 出版时间：15 December 2015
- 年：2015
- 卷：537
- 期：Complete
- 页码：197-202
- 全文大小：572 K
文摘
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E-screen and A-screen of two mixtures of organochlorine pesticides (OCP)
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Assay concentrations based on a previous breast cancer case–control study
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Only non-cytotoxic concentrations assayed
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Both OCP mixtures induce proliferation mediated by oestrogen receptor.
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OCP mixture of breast cancer patients exhibits additional androgenic activity.