Application of the Margin of Exposure (MoE) approach to substances in food that are genotoxic and carcinogenic: Example: Benzene, CAS: 71–43-2

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• 作者：Benjamin Smith ; Peter Cadby ; Michael DiNovi ; R. Woodrow Setzer
• 关键词：Benzene ; Margin of exposure (MoE) ; Food
• 刊名：Food and Chemical Toxicology
• 出版年：2010
• 出版时间：January 2010
• 年：2010
• 卷：48
• 期：Supplement 1
• 页码：S49-S56
• 全文大小：383 K

文摘

The role of genotoxic events in the aetiology of benzene induced tumours cannot be ruled out. Dose response modelling of the data for benzene gave a BMDL10 for female Zymbal gland carcinoma of 17.6 mg/kg-bw/d following adjustment to daily average doses. The MOEs ranged from 2 x 10⁶ to 0.4 x 10⁶ depending on the assumptions used in the exposure estimation.