Application of the margin of exposure (MoE) approach to substances in food that are genotoxic and carcinogenic: Example: Methyleugenol, CASRN: 93-15-2
详细信息 查看全文
- 作者：Benjamin Smith ; Peter Cadby ; Jean-Charles Leblanc ; R. Woodrow Setzer
- 关键词：Methyleugenol ; Margin of exposure ; MoE
- 刊名：Food and Chemical Toxicology
- 出版年：2010
- 出版时间：January 2010
- 年：2010
- 卷：48
- 期：Supplement 1
- 页码：S89-S97
- 全文大小：253 K
文摘
The weight of evidence points to weak genotoxic activity of methyleugenol, the putative genotoxic carcinogen being 1′-sulphate ester metabolite. Dose response modelling of the data for methyleugenol gave a BMDL10 for male rat liver adenoma or carcinoma (combined) of 7.9 mg/kg-bw/d following adjustment to daily average doses. The MoEs ranged from 100 to 800 depending on the assumptions used in the exposure estimation.