MLL5 Orchestrates a Cancer Self-Renewal State by Repressing the Histone Variant H3.3 and Globally Reorganizing Chromatin
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- 作者：Marco Gallo1 ; Fiona J. Coutinho1 ; 2 ; Robert J. Vanner1 ; 2 ; Tenzin Gayden3 ; Stephen C. Mack1 ; 4 ; 5 ; Alex Murison6 ; Marc Remke1 ; Ren Li7 ; Naoya Takayama6 ; Kinjal Desai8 ; Lilian Lee1 ; Xiaoyang Lan1 ; 2 ; Nicole I. Park1 ; 2 ; Dalia Barsyte-Lovejoy6 ; 9 ; David Smil6 ; 9 ; Dominik Sturm10 ; Michelle M. Kushida1 ; Renee Head1 ; Michael D. Cusimano11 ; 12 ; Mark Bernstein11 ; 13 ; Ian D. Clarke1 ; 15 ; John E. Dick6 ; Stefan M. Pfister10 ; Jeremy N. Rich4 ; Cheryl H. Arrowsmith6 ; 9 ; Michael D. Taylor1 ; 5 ; 11 ; Nada Jabado3 ; David P. Bazett-Jones7 ; Mathieu Lupien6 ; 14 ; mlupien@uhnres.utoronto.ca" class="auth_mail" title="E-mail the corresponding author ; Peter B. Dirks1 ; 2 ; 5 ; 11 ; peter.dirks@sickkids.ca" class="auth_mail" title="E-mail the corresponding author
- 刊名：Cancer Cell
- 出版年：2015
- 出版时间：14 December 2015
- 年：2015
- 卷：28
- 期：6
- 页码：715-729
- 全文大小：5638 K
文摘
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DNA methylomes of adult GBM self-renewing cells resemble H3.3-mutated pediatric GBM
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MLL5 represses H3.3 levels in adult GBM self-renewing cells
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MLL5 favors self-renewal and H3.3 favors differentiation in adult GBM
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An MLL5/H3.3 signature predicted two compounds that curb GBM self-renewal