NF-κB-Independent Role of IKKα/IKKβ in Preventing RIPK1 Kinase-Dependent Apoptotic and Necroptotic Cell Death during TNF Signaling
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- 作者：Yves Dondelinger1 ; 2 ; Sandrine Jouan-Lanhouet1 ; 2 ; Tatyana Divert1 ; 2 ; Emilie Theatre3 ; John Bertin4 ; Peter J. Gough4 ; Piero Giansanti5 ; 6 ; Albert J.R. Heck5 ; 6 ; Emmanuel Dejardin3 ; Peter Vandenabeele1 ; 2 ; 7 ; Mathieu J.M. Bertrand1 ; 2 ; mathieu.bertrand@irc.vib-ugent.be" class="auth_mail" title="E-mail the corresponding author
- 刊名：Molecular Cell
- 出版年：2015
- 出版时间：1 October 2015
- 年：2015
- 卷：60
- 期：1
- 页码：63-76
- 全文大小：4774 K
文摘
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IKKα/IKKβ prevent RIPK1 kinase-dependent death independently of NF-κB activation
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IKKα/IKKβ directly phosphorylate RIPK1 in TNFR1 complex I
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Impaired phosphorylation of RIPK1 correlates with enhanced binding to FADD/caspase-8
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IKK kinase inhibition induces TNF-mediated RIPK1 kinase-dependent cell death in vivo