Young Patients With Diabetes Have Decreased Cerebrovascular Reactivity Under Hypercapneic Conditions

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• 作者：Virginia W. Lin ; CPNP ; MSN^a ; ^{vlin@maimonidesmed.org" class="auth_mail" title="E-mail the corresponding author} ; Yuri Brosgol ; MD^a ; Peter Homel ; PhD^b ; Emily Hsu ; MD^c ; Noorjahan Ali ; MD^c ; Manjula Chatterjee ; MD^d ; Steven G. Pavlakis ; MD^a
• 关键词：transcranial Doppler ; cerebral blood flow ; hypercapnia ; adolescents and youth
• 刊名：Pediatric Neurology
• 出版年：2015
• 出版时间：December 2015
• 年：2015
• 卷：53
• 期：6
• 页码：498-502
• 全文大小：481 K

文摘

Adult diabetic patients have an abnormal cerebrovascular response to hypercapnia, but there are few studies focused on diabetes mellitus type 1 and cerebral blood flow in pediatric or adolescent patients. We hypothesize that young patients with diabetes exhibit a different response to hypercapnia than normal control counterparts.

Methods

Using transcranial Doppler techniques, we compared young diabetic patients with healthy controls by measuring cerebral blood velocity before and during carbon dioxide challenge.

Results

Subjects with diabetes had decreased cerebral blood velocity reactivity when compared with the control group (P = 0.005).

Conclusion

Our results suggest cerebrovascular dysfunction in diabetic patients beginning at an early age. The possibility of long-term implications for cerebrovascular disease demonstrates the need for further studies in the pediatric and adolescent diabetic population to better understand this prevalent condition.