Analysis of a Genetic Polymorphism in the Costimulatory Molecule TNFSF4 with Hematopoietic Stem Cell Transplant Outcomes
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- 作者：Peter T. Jindra1 ; Susan E. Conway1 ; Stacy M. Ricklefs2 ; Stephen F. Porcella2 ; Sarah L. Anzick2 ; Mike Haagenson3 ; Tao Wang4 ; Stephen Spellman3 ; Edgar Milford1 ; Peter Kraft5 ; David H. McDermott6 ; Reza Abdi1 ; rabdi@rics.bwh.harvard.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：Gene polymorphism ; Costimulation ; Hematopoietic stem cell transplantation ; Outcomes ; Infection ; GVHD
- 刊名：Biology of Blood and Marrow Transplantation
- 出版年：2016
- 出版时间：January 2016
- 年：2016
- 卷：22
- 期：1
- 页码：27-36
- 全文大小：1254 K
文摘
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Analysis of SNPs in costimulatory molecules effect HSCT outcomes.
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A total of 2345 donor–recipient pairs from two cohorts were included in this study.
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Potential improved patient outcomes with TNFSF4 rs10912564CC genotyped donors.
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The C variant of SNP rs10912564 creates a binding site for Myb compared with T.