NRL-Regulated Transcriptome Dynamics of Developing Rod Photoreceptors

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• 作者：Jung-Woong Kim¹ ; ² ; ⁷ ; Hyun-Jin Yang¹ ; ⁷ ; Matthew John Brooks¹ ; ⁷ ; Lina Zelinger¹ ; Gö ; khan Karakü ; lah¹ ; ⁸ ; Norimoto Gotoh¹ ; ³ ; Alexis Boleda¹ ; Linn Gieser¹ ; Felipe Giuste¹ ; Dustin Thad Whitaker¹ ; ⁴ ; Ashley Walton¹ ; Rafael Villasmil⁵ ; Jennifer Joanna Barb⁶ ; Peter Jonathan Munson⁶ ; Koray Dogan Kaya¹ ; Vijender Chaitankar¹ ; Tiziana Cogliati¹ ; Anand Swaroop¹ ; ⁹ ; ^{swaroopa@nei.nih.gov}
• 关键词：organogenesis ; photoreceptor differentiation ; neuronal development ; next generation sequencing ; RNA-seq ; basic motif leucine zipper ; transcription ; gene regulation ; retina ; Maf
• 刊名：Cell Reports
• 出版年：2016
• 出版时间：22 November 2016
• 年：2016
• 卷：17
• 期：9
• 页码：2460-2473
• 全文大小：4670 K
• 卷排序：17

文摘

Rod photoreceptor transcriptome dynamics parallels rod morphogenesis and maturation Transcriptome transition during rod fate stabilization is disrupted by loss of NRL De novo assembly reveals previously unannotated rod-specific transcripts Integrated network analysis identifies secondary hubs of the NRL-centered rod GRN