Characterizing MttA as a mitochondrial cis-aconitic acid transporter by metabolic engineering
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- 作者：Matthias G. Steigera ; b ; c ; matthias.steiger@boku.ac.at" class="auth_mail" title="E-mail the corresponding author ; Peter J. Puntc ; d ; peter.punt@ddna-biotech.com" class="auth_mail" title="E-mail the corresponding author ; Arthur F.J. Ramc ; A.F.J.Ram@biology.leidenuniv.nl" class="auth_mail" title="E-mail the corresponding author ; Diethard Mattanovicha ; b ; diethard.mattanovich@boku.ac.at" class="auth_mail" title="E-mail the corresponding author ; Michael Sauera ; b ; e ; michael.sauer@boku.ac.at" class="auth_mail" title="E-mail the corresponding author
- 关键词：Itaconic acid ; Aspergillus terreus ; Trans-aconitic acid ; Mitochondrial carrier protein ; Aspergillus niger ; Doxycycline ; Itaconate ; Aconitate
- 刊名：Metabolic Engineering
- 出版年：2016
- 出版时间：May 2016
- 年：2016
- 卷：35
- 期：Complete
- 页码：95-104
- 全文大小：2746 K
文摘
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MttA is a mitochondrial cis-aconitate transporter from A. terreus.
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MttA increases itaconic acid production.
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Metabolic engineering can be used to reveal the substrate characteristics of transport proteins in vivo.
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MttA can be used to engineer cells for the secretion of aconitic acid.