Calcium-Driven Folding of RTX Domain β-Rolls Ratchets Translocation of RTX Proteins through Type I Secretion Ducts
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- 作者：Ladislav Bumba1 ; Jiri Masin1 ; Pavel Macek1 ; Tomas Wald1 ; Lucia Motlova1 ; 2 ; Ilona Bibova1 ; Nela Klimova1 ; Lucie Bednarova3 ; Vaclav Veverka3 ; Michael Kachala4 ; Dmitri I. Svergun4 ; Cyril Barinka5 ; Peter Sebo1 ; sebo@biomed.cas.cz" class="auth_mail" title="E-mail the corresponding author
- 刊名：Molecular Cell
- 出版年：2016
- 出版时间：7 April 2016
- 年：2016
- 卷：62
- 期：1
- 页码：47-62
- 全文大小：5451 K
文摘
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Ca2+-driven folding of C-terminal “capping structures” triggers folding of RTX proteins
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Vectorial folding of RTX domains proceeds successively from C toward N terminus
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Ca2+-dependent RTX domain folding confers biological activity on RTX leukotoxins
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Ca2+-driven folding of RTX β-rolls ratchets protein translocation through T1SS ducts