Efficacy and tolerance of metronidazole and miconazole nitrate in treatment of vaginitis

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• 作者：Fabio Peixoto ; Aroldo Camargos ; Geraldo Duarte ; Iara Linhares ; Luis Bahamondes ; Alvaro Petracco
• 刊名：International Journal of Gynecology and Obstetrics
• 出版年：2008
• 出版时间：September 2008
• 年：2008
• 卷：102
• 期：3
• 页码：287-292
• 全文大小：140 K

文摘

Objective

To evaluate the efficacy and tolerability of a vaginal pessary containing 750 mg of metronidazole and 200 mg of miconazole nitrate used daily for 7 days in the treatment of vaginitis.

Methods

Ninety-two women with vaginitis participated in this phase 3 study using one vaginal pessary daily for 7 days. Gynecological and microbiological evaluations were carried out prior to and following treatment.

Results

Reductions occurred in symptoms and signs of vaginitis. Clinical cure rate was 87.7 % , while the cure rates according to microscopy and Candida albicans culture were 81.8 % and 73.9 % , respectively. The cure rate for bacterial vaginosis was 75 % and culture of Gardnerella vaginalis turned negative in 63.6 % of cases following treatment. The medication was well tolerated.

Conclusion

Use of a combination of 750 mg of metronidazole and 200 mg of miconazole in a single daily application was found to be effective in the treatment of the most common causes of vaginitis.