Ninety-two women with vaginitis participated in this phase 3 study using one vaginal pessary daily for 7 days. Gynecological and microbiological evaluations were carried out prior to and following treatment.
Reductions occurred in symptoms and signs of vaginitis. Clinical cure rate was 87.7 % , while the cure rates according to microscopy and Candida albicans culture were 81.8 % and 73.9 % , respectively. The cure rate for bacterial vaginosis was 75 % and culture of Gardnerella vaginalis turned negative in 63.6 % of cases following treatment. The medication was well tolerated.
Use of a combination of 750 mg of metronidazole and 200 mg of miconazole in a single daily application was found to be effective in the treatment of the most common causes of vaginitis.