Risperidone reduces limited access alcohol drinking in alcohol-preferring rats

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• 作者：Ingman ; Kimmo ; Honkanen ; Aapo ; Hyyti&auml ; Petri ; Huttunen ; Matti O. ; Korpi ; Esa R.
• 关键词：(Selected rat line) ; Alcohol preference ; Risperidone ; Food consumption ; Locomotor activity
• 刊名：European Journal of Pharmacology
• 出版年：2003
• 出版时间：May 9, 2003
• 年：2003
• 卷：468
• 期：2
• 页码：121-127
• 全文大小：155 K

文摘

An atypical antipsychotic drug risperidone reduced ethanol drinking of ethanol-preferring Alko, Alcohol (AA) rats in a limited access paradigm. Its effect was transient at a dose known to preferentially antagonize the 5-HT₂ receptors (0.1 mg/kg, s.c.), but long-lasting when the dose was increased to 1.0 mg/kg that also blocks dopamine D₂ receptors. Risperidone also reduced dose-dependently locomotor activity and limited access saccharin intake of the AA rats, indicating that its effect on ethanol drinking was not selective. Risperidone at 0.1 mg/kg given before four successive daily ethanol-drinking sessions significantly reduced the ethanol intake. These data from an animal model of high ethanol intake suggest that risperidone should be tested in various populations of alcoholics for reducing ethanol consumption.