Appb is required for the Mauthner cell development in zebrafish.

Down regulation of Appb causes decreased tail flip response induced by electrical stimulus.

Loss of Appb results in increased Notch signaling and reduced neural differentiation in the hindbrain.

Balanced Notch signaling rescues the Mauthner cell defects in Appb morphants.

First report to our knowledge that shows cell-specific function of amyloid precursor protein during neural development.