Identification and expression modulation of a C-type lectin domain family 4 homologue that is highly expressed in monocytes/macrophages in rainbow trout (Oncorhynchus mykiss)
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- 作者：Petronella Johanssona ; b ; Tiehui Wanga ; Bertrand Colletb ; Yolanda Corripio-Miyara ; 1 ; Milena M. Montea ; Christopher J. Secombesa ; c.secombes@abdn.ac.uk" class="auth_mail" title="E-mail the corresponding author ; Jun Zoua
- 关键词：Dendritic cell ; C-type lectin ; CLEC4/CD209 ; Rainbow trout ; Interleukin-4/13A ; Innate immunity ; Macrophage
- 刊名：Developmental & Comparative Immunology
- 出版年：2016
- 出版时间：January 2016
- 年：2016
- 卷：54
- 期：1
- 页码：55-65
- 全文大小：2452 K
文摘
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Cloned a rainbow trout C-type lectin we term CLEC4T1.
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We show it is expressed in immune tissues at the transcript and protein level.
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We show that LPS but not polyI:C can up-regulate this gene.
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We have generated a polyclonal antibody to trout CLEC4T1.
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We show by FACS analysis that the number CLEC4T1+ cells increase following exposure to rIL-4/13A ± LPS.