Anti-HCV immunoassays based on a multiepitope antigen and fluorescent lanthanide chelate reporters
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- 作者：Teppo Salminena ; tjsalm@utu.fi" class="auth_mail" title="E-mail the corresponding author ; Etvi Juntunena ; Navin Khannab ; c ; d ; Kim Petterssona ; Sheikh M. Talhaa
- 关键词：HCV ; Multiepitope protein ; Europium chelate ; Double-antigen ; Immunoassay ; Avidity index
- 刊名：Journal of Virological Methods
- 出版年：2016
- 出版时间：February 2016
- 年：2016
- 卷：228
- 期：Complete
- 页码：67-73
- 全文大小：640 K
文摘
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Single recombinant antigen with epitopes from different HCV proteins was developed.
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The antigen was used with fluorescent lanthanide chelate in HCV immunoassays.
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Indirect and double-antigen anti-HCV assays recognized all six genotypes of HCV.
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HCV double-antigen assays may suffer from low avidity antibodies of acute cases.