UVB irradiation induces rapid changes in galanin, substance P and c-fos immunoreactivity in rat dorsal root ganglia and spinal cord

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• 作者：Leila Etemadi ; ^{Leila.Etemadi@med.lu.se} ; Lina M.E. Pettersson ; Nils Danielsen
• 关键词：Lateral spinal nucleus ; Dorsal horn ; Inflammation ; Neuropeptides ; Pain translational model ; Immunoreactivity
• 刊名：Peptides
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：87
• 期：Complete
• 页码：71-83
• 全文大小：4857 K
• 卷排序：87

文摘

UVB irradiation of rat hind paws will induce inflammation as reflected by an almost two-fold increase in skin blood flow after 24 h. UVB induced inflammation will change the expression of galanin, SP and c-fos in DRG, dorsal horn, lateral spinal nucleus and around the central canal. Galanin is down-regulated in DRG neurons and up-regulated in dorsal horn, lateral spinal nucleus and around the central canal. UVB induced inflammation can induce c-fos activity in spinal cord by itself. UVB induced inflammation will induce increase of immunoreactivity for galanin and SP in the lateral spinal nucleus.