Neuronal management of energetic status in Parkinson's disease (PD) is reviewed.
Mitochondria, endoplasmic reticulum and lysosomes involvement in PD are discussed.
Mitochondrial dysfunction leads to neuronal metabolic re-programming in PD.
Increased neuronal glycolysis shifts down pentose-phosphate pathway (PPP) in PD.
Down-regulation of PPP in neurons may account for PD-associated oxidative stress.