Alterations of white matter structural networks in patients with non-neuropsychiatric systemic lupus erythematosus identified by probabilistic tractography and connectivity-based analyses

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• 作者：Man Xu^a ; ¹ ; Xiangliang Tan^b ; ¹ ; Xinyuan Zhang^a ; Yihao Guo^a ; Yingjie Mei^a ; ^c ; Qianjin Feng^a ; Yikai Xu^b ; ^{yikai.xu@163.com} ; Yanqiu Feng^a ; ^{foree@163.com}
• 关键词：Non-neuropsychiatric systemic lupus erythematosus ; Diffusion tensor imaging ; White matter ; Probabilistic tractography ; Graph theory
• 刊名：NeuroImage: Clinical
• 出版年：2017
• 出版时间：2017
• 年：2017
• 卷：13
• 期：Complete
• 页码：349-360
• 全文大小：1552 K
• 卷排序：13

文摘

The global integration and local specialization of the white matter networks were disrupted in non-NPSLE patients. The brain regions with significantly altered nodal properties were mainly involved in language, visual, and DMN systems. The properties of some identified regions presented negative correlations with the SLE disease activity index scores. The distribution pattern of the hubs measured by nodal degree was altered in the non-NPSLE patients. The non-NPSLE group exhibited a subnetwork of decreased connectivity and a subnetwork of increased connectivity.