刊名:Biochemical and Biophysical Research Communications
出版年:2017
出版时间:22 January 2017
年:2017
卷:482
期:4
页码:1073-1079
全文大小:2071 K
卷排序:482
文摘
β-lapachone (β-L) inhibits RANKL-mediated osteoclastogenesis. β-L increases the intracellular NAD+/NADH ratio, which is followed by activation of AMPK in osteoclasts. The activation of AMPK by β-L inhibits c-Fos and NFATc1 expression in RANKL-induced osteoclastogenesis. β-L also suppresses c-Fos and NFATc1 expression via downregulation of PPARγ and PGC1β expression.