Dichotomous effects of aryl hydrocarbon receptor (AHR) activation on human fetoplacental endothelial cell function
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- 作者：Anna Palatnika ; anatlivs@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Hong Xinb ; Emily J. Sub
- 刊名：Placenta
- 出版年：2016
- 出版时间：August 2016
- 年：2016
- 卷：44
- 期：Complete
- 页码：61-68
- 全文大小：1366 K
文摘
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Benzo[a]pyrene (BaP) induces cyclooxygenase-2 and increases 6-keto PGF1α.
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Fetoplacental endothelial cell migration and tube formation are inhibited by BaP.
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BaP effects on fetoplacental endothelial cells occur via aryl hydrocarbon receptor.
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Angiogenic impairment mediates adverse effects of BaP on fetoplacental vasculature.