Electrochemical evaluation of antioxidant capacity in pharmaceutical antioxidant excipient of drugs on guanine-based modified electrode
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- 作者：Yuan Yue ; Bao Zhihong ; Li Sanming ; Zhao Kun ; zklts@163.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Hydroxyl radicals ; Antioxidant capacity ; Guanine biosensor ; TiO2 nanoparticles ; Drug ; Pharmaceutical antioxidant excipient
- 刊名：Journal of Electroanalytical Chemistry
- 出版年：2016
- 出版时间：1 July 2016
- 年：2016
- 卷：772
- 期：Complete
- 页码：58-65
- 全文大小：571 K
文摘
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A guanine-biosensor for the antioxidant capacity quantification of antioxidants in pharmaceutical excipients was reported.
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The antioxidant capacity is based on the changes of the oxidation current of guanine on a TiO2NPs/MWCNTs modified electrode.
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TiO2NPs were used owing to their ability to generate the hydroxyl radicals and to immobilize the guanine.