General screening and optimization strategy for fast chiral separations in modern supercritical fluid chromatography

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• 作者：Lucie Nová ; ková ; ^a ; ^nol@email.cz ; Michal Dou&scaron ; a^b
• 关键词：Supercritical fluid chromatography ; SFC ; Chiral stationary phases ; Organic modifier ; Combined additive ; Enantioselectivity ; Pharmaceuticals
• 刊名：Analytica Chimica Acta
• 出版年：2017
• 出版时间：15 January 2017
• 年：2017
• 卷：950
• 期：Complete
• 页码：199-210
• 全文大小：2200 K
• 卷排序：950

文摘

General screening approach for fast SFC chiral separation was developed. The best enantioselectivity in SFC was obtained with tris(3,5-dimethylphenylcarbamate) substituted stationary phases based on both amylose and cellulose. Combined additive composed of 0.1% DEA and 0.1% TFA provided the best enantioselectivity for generic screening. Volatile buffers were found to be a viable option for SFC chiral screening. Tetrahydrofuran was the most convenient injection solvent for chiral SFC analyses.