Genetic polymorphisms of pharmacogenomic VIP variants in the Kyrgyz population from northwest China

详细信息    查看全文

• 作者：Zulfiya Yunus ; Lijun Liu ; Hong Wang ; Le Zhang ; Xiaolan Li ; Tingting Geng ; Longli Kang ; Tianbo Jin ; Chao Chen
• 关键词：VIP variants ; very important pharmacogenetic variants ; CHB ; Han Chinese in Beijing China ; JPT ; the Japanese in Tokyo Japan ; CEU ; a northern and western Europe population ; YRI ; the Yoruba in Ibadan Nigeria ; SNP ; single nucleotide polymorphism ; HWE ; Hardy&n
• 刊名：Gene
• 出版年：2013
• 出版时间：15 October, 2013
• 年：2013
• 卷：529
• 期：1
• 页码：88-93
• 全文大小：521 K

文摘

Pharmacogenomic variant information is well known for major human populations; however, this information is less commonly studied in minorities. In the present study, we genotyped 85 very important pharmacogenetic (VIP) variants (selected from the PharmGKB database) in the Kyrgyz population and compared our data with other four major human populations including Han Chinese in Beijing, China (CHB), the Japanese in Tokyo, Japan (JPT), a northern and western Europe population (CEU), and the Yoruba in Ibadan, Nigeria (YRI). There were 13, 12 and 16 of the selected VIP variant genotype frequencies in the Kyrgyz which differed from those of the CHB, JPT and CEU, respectively (p < 0.005). In the YRI, there were 32 different variants, compared to the Kyrgyz (p < 0.005). Genotype frequencies of ADH1B, AHR, CYP3A5, PTGS2, VDR, and VKORC1 in the Kyrgyz differed widely from those in the four populations. Haplotype analyses also showed differences among the Kyrgyz and the other four populations. Our results complement the information provided by the database of pharmacogenomics on Kyrgyz. We provide a theoretical basis for safer drug administration and individualized treatment plans for the Kyrgyz. We also provide a template for the study of pharmacogenomics in various ethnic minority groups in China.