Pharmacogenetic reactivation of the original engram evokes an extinguished fear memory

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• 作者：Takahiro Yoshii^c ; ^d ; Hiroshi Hosokawa^d ; Naoki Matsuo^a ; ^b ; ^c ; ^{n-matsuo@mbn.med.osaka-u.ac.jp}
• 关键词：Contextual fear memory ; Extinction ; Transgenic mice ; PTSD
• 刊名：Neuropharmacology
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：113
• 期：part_PA
• 页码：1-9
• 全文大小：2400 K
• 卷排序：113

文摘

Transgenic mice in which engram cells can be reactivated via DREADD were generated. Pharmacogenetic reactivation of engram cells revived extinguished fear memory. Pharmacogenetic activation of memory-unrelated ensembles failed to evoke freezing. Pharmacogenetic reactivation of engram cells did not result in relearning.