EphB2 reverse signaling regulates learned opiate tolerance via hippocampal function
详细信息 查看全文
- 作者：Sofia Huroya ; Ashlin Kanawatya ; Lilia Magomedovaa ; Carolyn L. Cumminsa ; Susan R. Georgeb ; Derek van der Kooyc ; Jeffrey T. Hendersona ; jeff.henderson@utoronto.ca" class="auth_mail" title="E-mail the corresponding author
- 关键词：Morphine ; Eph receptors ; Competitive interference ; Passive avoidance ; Gene knockout
- 刊名：Behavioural Brain Research
- 出版年：2016
- 出版时间：1 March 2016
- 年：2016
- 卷：300
- 期：Complete
- 页码：85-96
- 全文大小：1996 K
文摘
- •
Identifies mechanistic role for EphB2 reverse signaling in opiate tolerance.
- •
Effect of EphB2 opposes that previously described for EphB1 signaling.
- •
EphB2 accelerates opiate tolerance via hippocampal-dependent mechanism.
- •
Provides mechanistic basis for prior work on associative cues and opiate tolerance.