PEGylated polycyanoacrylate nanoparticles as vector for drug delivery in prion diseases
详细信息 查看全文
- 作者：Calvo ; Pilar ; Gouritin ; Bruno ; Brigger ; Irè ; ne ; Lasmezas ; Corinne ; Deslys ; Jean-Philippe ; et. al.
- 关键词：Nanoparticles ; Brain delivery ; Polycyanoacrylate ; Long-circulating systems ; Prion diseases
- 刊名：Journal of Neuroscience Methods
- 出版年：2001
- 出版时间：September 30, 2001
- 年：2001
- 卷：111
- 期：2
- 页码：151-155
- 全文大小：124 K
文摘
PEGylated polymeric nanoparticles are hereby presented as a potential efficient drug carrier for the delivery of active therapeutic molecules in prion experimental diseases. Based on their blood long-circulating characteristics, these PEGylated particles made by the amphiphilic copolymer poly [methoxy poly(ethylene glycol) cyanoacrylate-co-hexadecyl cyanoacrylate] (PEG-PHDCA), showed comparatively conventional non-PEGylated nanoparticles, a higher uptake by the spleen and the brain which are both the target tissues of PrPres accumulation in scrapie infected animals.