Synthesized different derivatives of low molecular fucoidan extracted from Laminaria japonica

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• 作者：Jing Wang ; Feng Wang ; Quanbin Zhang ; Zhongshan Zhang ; Xuelian Shi ; Pengcheng Li
• 关键词：Low molecular fucoidan ; Derivatives ; Antioxidant activity
• 刊名：International Journal of Biological Macromolecules
• 出版年：2009
• 出版时间：1 June 2009
• 年：2009
• 卷：44
• 期：5
• 页码：379-384
• 全文大小：401 K

文摘

Six low molecular fucoidan (DFPS) derivatives were synthesized successfully, and their potential antioxidant activities were investigated employing various established in vitro systems. All DFPS derivatives possessed considerable antioxidant activity, and had stronger antioxidant ability than DFPS in certain tests. The benzoylated DFPS (PHDF) showed strongest scavenging activity on superoxide, hydroxyl and 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical, however, DFPS exhibited greatest reducing power. Available data suggested that substituted groups of DFPS played an important role on antioxidant activity, and the mechanism on influence the antioxidant activity of samples of substituted group was indicated.