Pharmacokinetic studies of phellodendrine in rat plasma and tissues after intravenous administration using ultra-high performance liquid chromatography-tandem mass spectrometry
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- 作者：Yi Li ; Xin-Guang Liu ; Hui-Ying Wang ; Xin Dong ; Wen Gao ; Xiao-Jun Xu ; Ping Li ; liping2004@126.com" class="auth_mail" title="E-mail the corresponding author ; Hua Yang ; 104yang104@163.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Phellodendrine ; Pharmacokinetic ; Tissue distribution ; UHPLC&ndash ; MS/MS ; Cortex phellodendri
- 刊名：Journal of Chromatography B, Analytical Technologies in the Biomedical and Life Sciences
- 出版年：2016
- 出版时间：1 September 2016
- 年：2016
- 卷：1029-1030
- 期：Complete
- 页码：95-101
- 全文大小：1241 K
文摘
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A simple and sensitive UHPLC–MS/MS method was developed to determinate phellodendrine in rat plasma and tissues.
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The method was fully validated and successfully applied to pharmacokinetic study of phellodendrine.
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Systemic exposure to phellodendrine in rats was investigated.
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Phellodendrine eliminated in 2 h and accumulated mostly in liver and kidney.