The individual and combined effects of phenmetrazine and mgluR2/3 agonist LY379268 on the motivation to self-administer cocaine
详细信息 查看全文
- 作者：Anushree N. Karkhanisa ; Thomas J.R. Beveridgeb ; Bruce E. Bloughc ; Sara R. Jonesa ; Mark J. Ferrisa ; mferris@wakehealth.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：Combination therapy ; LY379268 ; mGluR2/3 agonist ; Phenmetrazine ; Dopamine releaser ; Cocaine self administration
- 刊名：Drug and Alcohol Dependence
- 出版年：2016
- 出版时间：1 September 2016
- 年：2016
- 卷：166
- 期：Complete
- 页码：51-60
- 全文大小：2119 K
文摘
- •
LY379268, an mGluR2/3 agonist, reduced breakpoints for cocaine by 40%.
- •
Phenmetrazine, a dopamine releaser, reduced breakpoints for cocaine by about 25% maximum.
- •
The combination of the two drugs showed a supra-additive effect in reducing breakpoints for cocaine by as much as 70%.
- •
Neither LY379268 nor phenmetrazine, showed any nonspecific locomotor effects.