Antipsychotic drugs
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- 作者：James W. Dear ; D Nicholas Bateman
- 关键词：Antipsychotics ; atypical antipsychotics ; butyrophenones ; phenothiazines ; thioxanthenes
- 刊名：Medicine
- 出版年：2016
- 出版时间：March 2016
- 年：2016
- 卷：44
- 期：3
- 页码：143-144
- 全文大小：71 K
文摘
Antipsychotic drugs can be classified by chemical structure and receptor specificity. Older phenothiazine antipsychotics act on a wide range of receptor systems, whereas the newer butyrophenone and atypical drugs are more specific, particularly at dopamine receptors. In overdose, adverse events include acute extrapyramidal reactions, sedation and cardiovascular effects including, potentially, arrhythmias. Phenothiazine antipsychotics often have anticholinergic, antihistamine and α-adrenoceptor antagonist activity, resulting in greater toxicity in overdose.