Neuroleptic drugs in the treatment of tuberculosis: Minimal inhibitory concentrations of different phenothiazines against Mycobacterium tuberculosis

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• 作者：Silvan Vesenbeckh^a ; ^{silvan.vesenbeckh@helios-kliniken.de" class="auth_mail" title="E-mail the corresponding author} ; David Krieger^a ; ^{david.krieger@helios-kliniken.de" class="auth_mail" title="E-mail the corresponding author} ; Gudrun Bettermann^b ; ^{gudrun.bettermann@berlin.de" class="auth_mail" title="E-mail the corresponding author} ; Nicolas Schö ; nfeld^a ; ^{nicolas.schoenfeld@helios-kliniken.de" class="auth_mail" title="E-mail the corresponding author} ; Torsten Thomas Bauer^a ; ^c ; ^{torsten.bauer@helios-kliniken.de" class="auth_mail" title="E-mail the corresponding author} ; Holger Rü ; ssmann^b ; ^{holger.ruessmann@helios-kliniken.de" class="auth_mail" title="E-mail the corresponding author} ; Harald Mauch^b ; ^{herald.mauch@helios-kliniken.de" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Public health ; Drug development ; Guideline ; Antibiotic resistance ; Efflux pump
• 刊名：Tuberculosis
• 出版年：2016
• 出版时间：May 2016
• 年：2016
• 卷：98
• 期：Complete
• 页码：27-29
• 全文大小：184 K

文摘

Due to an increase of drug resistant TB, alternative drugs that are not currently listed in the WHO guidelines on MDR TB treatment are currently being evaluated. Our group tested 100 susceptible, 20 MDR and 2 XDR Mtb strains against the phenothiazine derivatives thioridazine, trifluoperazine and triflupromazine. MIC testing was performed on Middlebrook 7H10 agar and was defined as the lowest drug concentration that inhibits ≥99% of the bacterial population. We confirm very good in vitro activity of phenothiazines against Mycobacterium tuberculosis. In >77% of all strains MICs of ≤10 μg/ml were found.