Microglia in the TBI brain: The good, the bad, and the dysregulated
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- 作者：David J. Loane ; dloane@anes.umm.edu" class="auth_mail" title="E-mail the corresponding author ; Alok Kumar
- 关键词：Traumatic brain injury ; Neuroinflammation ; Microglia ; Macrophage ; Phenotype ; M1-like ; M2-like ; Polarization ; Neurodegeneration ; Repair
- 刊名：Experimental Neurology
- 出版年：2016
- 出版时间：January 2016
- 年：2016
- 卷：275
- 期：part_P3
- 页码：316-327
- 全文大小：712 K
文摘
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Microglia play a critical role in neuroinflammation following TBI
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Microglial activation has beneficial and detrimental effects on neurons after TBI
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Microglial phenotypic and functional responses may account for these dual effects
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Treatments that alter M1/M2-like balance may enhance CNS repair after TBI