Participation of protein kinases in cytotoxic and proapoptotic effects of ethylene glycol ethers and their metabolites in SH-SY5Y cells
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- 作者：Bartosz Pomierny ; Ph.D.a ; b ; bartosz.pomierny@uj.edu.pl" class="auth_mail" title="E-mail the corresponding author ; Kjell Fuxe ; Prof.b ; Kjell.Fuxe@ki.se" class="auth_mail" title="E-mail the corresponding author ; Weronika Krzyżanowska ; M.Sc.a ; weronika.krzyzanowska@uj.edu.pl" class="auth_mail" title="E-mail the corresponding author ; Magdalena Regulska ; Ph.D.c ; regulska@if-pan.krakow.pl" class="auth_mail" title="E-mail the corresponding author ; Żaneta Broniowska ; M.Sc.a ; zaneta.broniowska@uj.edu.pl" class="auth_mail" title="E-mail the corresponding author ; Bogusława Budziszewska ; Prof.a ; c ; boguslawa.budziszewska@uj.edu.pl" class="auth_mail" title="E-mail the corresponding author
- 关键词：EGEs ; ethylene glycol ethers ; BE ; 2-butoxyethanol ; BA ; butoxyacetic acid ; EE ; 2-ethoxyethanol ; EA ; ethoxyacetic acid ; PHE ; 2-phenoxyethanol ; PHA ; phenoxyacetic acid
- 刊名：Toxicology in Vitro
- 出版年：2016
- 出版时间：October 2016
- 年：2016
- 卷：36
- 期：Complete
- 页码：153-163
- 全文大小：1342 K
文摘
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EGEs and their metabolites exhibit severe cytotoxic properties on neuroblastoma cells.
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EGEs and their metabolites, affecting different protein kinases, stimulate apoptosis.
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EGEs may be involved in the initiation of neurodegeneration process.
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EGEs and their metabolites significantly increase reactive oxygen species (ROS) production.