Kinetics study on reactive extraction of hydroxy-(2-methyl-phenyl)-acetic acid enantiomers from organic solution by HP-¦Â-CD

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• 作者：Kewen Tang^a ; ^{tangkewen@sina.com} ; Jingjing Luo^b ; Panliang Zhang^a ; Congshan Zhou^a ; Jianmin Yi^a
• 关键词：Liquid&ndash ; liquid extraction ; Kinetics ; Hydroxy-(2-methyl-phenyl)-acetic acid ; Enantiomers
• 刊名：Chemical Engineering Research and Design
• 出版年：2013
• 出版时间：May, 2013
• 年：2013
• 卷：91
• 期：5
• 页码：919-924
• 全文大小：574 K

文摘

Kinetics data is important for the reliable scale-up of a lab-scale process and for selection, design and operation of related equipment. This paper reports on the kinetics study for reactive extraction of hydroxy-(2-methyl-phenyl)-acetic acid (HA) enantiomers by hydroxypropyl-¦Â-cyclodextrin (HP-¦Â-CD) from the organic phase to the aqueous phase. The theory of extraction with chemical reaction was used. The effects of agitation speed, interfacial area, pH value of aqueous phase, initial concentration of HA enantiomers and initial concentration of extractant on the specific rate of extraction were investigated. The reactions have been found to be first order in HA and second order in HP-¦Â-CD with the forward rate constants of 4.873 ¡Á 10^?4 m⁶/(mol² s) for R-HA and 4.343 ¡Á 10^?4 m⁶/(mol² s) for S-HA, respectively.