Changes of lipoproteins in phenylalanine hydroxylase-deficient children during the first year of life
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- 作者：Hironori Nagasakaa ; j ; nagasa-hirono@k2.dion.ne.jp" class="auth_mail ; Hirokazu Tsukaharab ; Yoshiyuki Okanoc ; Ken-ichi Hiranod ; Toshihiro Sakuraie ; Shu-Ping Huie ; Toshihiro Ohuraf ; Hiromi Usuig ; Tohru Yorifujih ; Satoshi Hirayamai ; Akira Ohtakej ; Takashi Miidai
- 关键词：PKU ; phenylketonuria ; PAH ; phenylalanine hydroxylase
- 刊名：Clinica Chimica Acta
- 出版年：10 June 2014
- 年：2014
- 卷：433
- 期：Complete
- 页码：1-4
- 全文大小：289 K
文摘
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We examined lipoproteins in phenylalanine hydroxylase deficiency during the first years of life.
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At birth, decrease of high-density lipoprotein predominated over low-density lipoprotein.
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At 3 and 12 months, decrease of low-density lipoprotein predominated over high-density lipoprotein.
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The decreases of lipoproteins in phenylketonuria were greater than those in benign hyperphenylalaninemia.
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Phenylalanine hydroxylase deficiency strongly influences on lipoproteins during early life.