An iminosugar-based heparanase inhibitor heparastatin (SF4) suppresses infiltration of neutrophils and monocytes into inflamed dorsal air pouches
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- 作者：Mayumi Suea ; Nobuaki Higashia ; b ; higashi@mol.f.u-tokyo.ac.jp" class="auth_mail" title="E-mail the corresponding author ; Hiroaki Shidaa ; Yusuke Koganea ; Yoshio Nishimurac ; Hayamitsu Adachic ; Elzbieta Kolaczkowskad ; Magdalena Kepkad ; Motowo Nakajimae ; Tatsuro Irimuraa ; f ; g ; t-irimura@juntendo.ac.jp" class="auth_mail" title="E-mail the corresponding author
- 关键词：BM ; basement membrane ; BSA ; bovine serum albumin ; ECM ; extracellular matrix ; ELISA ; enzyme-linked immunosorbent assay ; FCS ; fetal calf serum ; fMLP ; formyl-methionyl-leucyl-phenylalanine ; HS ; heparan sulfate ; HSPG ; heparan sulfate proteoglycan ; Hpse ; heparanase ; HRP ; horseradish peroxidase ; mAb ; monoclonal antibody ; SVBCE ; SV40-transformed bovine corneal endothelial cells
- 刊名：International Immunopharmacology
- 出版年：2016
- 出版时间：June 2016
- 年：2016
- 卷：35
- 期：Complete
- 页码：15-21
- 全文大小：666 K
文摘
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Heparastatin (SF4) lowered infiltrating cell numbers in inflamed air pouches.
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Heparastatin (SF4) significantly suppressed invasion of neutrophils in vitro.
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Heparastatin (SF4) suppressed degradation of heparan sulfate in basement membrane.
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Therapeutic application of a heparanase inhibitor in inflammation is proposed.