Anti-inflammatory isoflavonoids from the rhizomes of Iris germanica
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- 作者：Rahman ; Atta-ur- ; Nasim ; Shama ; Baig ; Irfan ; Jalil ; Saima ; Orhan ; Ilkay ; Sener ; Bilge ; Choudhary ; M. Iqbal
- 关键词：Iris germanica L. ; Iridaceae ; Isoflavones ; Anti-inflammatory assay ; WST ; 1 ; 2(4-iodophenyl)-3-(4-nitrophenyl)-5-(2 ; 4-disulfophenyl)-2H-tetrazolium mono sodium salt ; fMLP ; N-formyl-methionine-leucine-phenylalanine ; HBSS ; Hank46 ; s balanced salt solution
- 刊名：Journal of Ethnopharmacology
- 出版年：2003
- 出版时间：June, 2003
- 年：2003
- 卷：86
- 期：2-3
- 页码：177-180
- 全文大小：85.2 K
文摘
The anti-inflammatory activity of nine isoflavonoids 5,7-dihydroxy-3-(3′-hydroxy-4′,5′dimethoxy)-8-methoxy-4H-1-benzopyran-4-one 1, 5,7-dihydroxy-3-(3′-hydroxyl-4′, 5′-dimethoxy)-6-methoxy-4H-1-benzopyran-4-one 2, 5, 7-dihydroxy-3-(4′-hydroxy)-6-methoxy-4H-1-benzopyrane-4-one 3, 5-hydroxy-3-(4′-hydroxy)-6,7-methylenedioxy-4H-1-benzopyran-4-one 4, 5-hydroxy-3-(4′-methoxy)-6,7-methylenedioxy-4H-1-benzopyran-4-one 5, 5-methoxy-3-(4′-hydroxy)-6,7-methyenedioxy-4H-1-benzopyran-4-one 6, 5,7-dihydroxy-3-(3′-hydroxy-4′-methoxy)-6-methoxy-4H-1-benzopyran-4-one 7, 5,7-dihydroxy-3-(3′-methoxy-4′-hydroxy)-6-methoxy-4H-1-benzopyran-4-one 8, and isopeonol 9 determined by a spectrophotometric assay using the activated human neurtrophilis. These isoflavonoids were isolated from an important folkloric medicinal plant Irsa (Iris germanica L.), a member of the family Iridaceae. Structures of these compounds were identified by spectral comparison with the reported data and active members of this group adds into the growing number of non-steroidal anti-inflammatory agents.