A new approach to the synthesis of l-3-hydroxy-4-methoxy-5-methyl-phenylalanine derivatives from l-tyrosine
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- 作者：Ruijiao Chen ; Deguang Zhu ; Zuoqiang Hu ; Zhiming Zheng ; Xiaochuan Chen
- 刊名：Tetrahedron: Asymmetry
- 出版年：2010
- 出版时间：29 January 2010
- 年：2010
- 卷：21
- 期：1
- 页码：39-42
- 全文大小：335 K
文摘
A practical procedure to regioselectively install a methyl group and a phenolic hydroxyl group onto l-tyrosine was developed. By using this approach, protected l-3-hydroxy-4-methoxy-5-methyl-phenylalanine and l-3-hydroxy-4-methoxy-5-methyl-phenylalanol, which are utilized in efficient syntheses of the relevant tetrahydroisoquinoline alkaloids, were prepared conveniently with high yield.