文摘
Tgfβ2, Bmp4 and Foxc1 are direct downstream targets of Pax6 in the developing iris. Pax6 +/− mice exhibit reduced Tgfβ2, Bmp4 and Foxc1 protein in the optic cup margin. Mutations in Foxc1, Bmp4 and Tgfβ2 cause similar phenotype to Pax6 mutations. Downstream targets of Pax6 are potential therapeutic targets for aniridia.