Effect of axotomy and 17β-estradiol on P2X7 receptor expression pattern in the hypoglossal nucleus of ovariectomized mice
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- 作者：B. Barabá ; sia ; A. Csondora ; T. Martí ; n-Pozasa ; &dagger ; ; A.M. Pulupa Sá ; ncheza ; &dagger ; ; G. Antalffyc ; L. Sikló ; sa ; U. Gó ; mez-Pinedob ; Á ; . Pá ; rducza ; Z. Hoyka ; hoyk.zsofia@brc.mta.hu" class="auth_mail" title="E-mail the corresponding author
- 关键词：DAPI ; 4&prime ; 6-diamino-2-phenylindole ; ER ; estrogen receptor ; NGS ; normal goat serum ; NHS ; normal horse serum ; PB ; phosphate buffer ; PBS ; phosphate-buffered saline ; SDS ; sodium dodecyl sulfate ; SDS&ndash ; PAGE ; sodium dodecyl sulfate polyacrylamide gel electrophoresis ; TTBS ; tween 20 in tris buffered saline
- 刊名：Neuroscience
- 出版年：2016
- 出版时间：5 April 2016
- 年：2016
- 卷：319
- 期：Complete
- 页码：107-115
- 全文大小：1389 K
文摘
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P2X7 receptor expression localized on microglia is increased following axotomy.
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P2X7 receptor expression localized on injured neurons is decreased.
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17β-Estradiol enhances the effect of axotomy on P2X7 receptor expressional changes.
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20">17β-Estradiol may act through classical estrogen receptors in neurons but not in microglia.