Elevated nuclear sphingoid base-1-phosphates and decreased histone deacetylase activity after fumonisin B1 treatment in mouse embryonic fibroblasts
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- 作者：Nicole M. Gardnera ; nicolegardner@creighton.edu" class="auth_mail" title="E-mail the corresponding author ; Ronald T. Rileyb ; Jency L. Showkerb ; Kenneth A. Vossb ; Andrew J. Sachsa ; Joyce R. Maddoxa ; Janee B. Gelineau-van Waesa
- 关键词：ABC ; ATP binding cassette ; CerS ; ceramide synthase ; ELEM ; equine leukoencephalomalacia ; FB1 ; fumonisin B1 ; Gapdh ; glyceraldehyde 3-phosphate dehydrogenase ; GPCR ; G protein-coupled receptor ; HDAC ; histone deacetylase ; Lpp ; lipid phosphate phosphatase ; MEF ; mouse embryonic fibroblast ; Na3VO4 ; sodium orthovanadate ; NaF ; sodium fluoride ; NES ; nuclear export signal ; NLS ; nuclear localization signal ; NTD ; neural tube defect ; PDGF ; platelet-derived growth factor ; PMSF ; phenylmethanesulfonyl fluoride ; P
- 刊名：Toxicology and Applied Pharmacology
- 出版年：2016
- 出版时间：1 May 2016
- 年：2016
- 卷：298
- 期：Complete
- 页码：56-65
- 全文大小：966 K
文摘
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FB1 treatment results in accumulation of Sa1P primarily in the nucleus of MEFs.
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FB1 treatment and elevated nuclear Sa1P are associated with HDAC inhibition.
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Sphk2 inhibition alone significantly decreases nuclear Sa1P in response to FB1.
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Sphk1 and Sphk2 inhibitors prevent nuclear Sa1P accumulation in response to FB1.