Multivalent Histone and DNA Engagement by a PHD/BRD/PWWP Triple Reader Cassette Recruits ZMYND8 to K14ac-Rich Chromatin

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• 作者：Pavel Savitsky¹ ; ¹⁰ ; Tobias Krojer¹ ; ¹⁰ ; Takao Fujisawa² ; ¹⁰ ; Jean-Philippe Lambert³ ; Sarah Picaud¹ ; Chen-Yi Wang² ; Erin K. Shanle⁴ ; Krzysztof Krajewski⁴ ; Hans Friedrichsen² ; Alexander Kanapin⁵ ; Colin Goding² ; Matthieu Schapira⁶ ; ⁷ ; Anastasia Samsonova⁵ ; Brian D. Strahl⁴ ; ⁸ ; Anne-Claude Gingras³ ; ⁹ ; Panagis Filippakopoulos¹ ; ² ; ¹¹ ; ^{panagis.filippakopoulos@sgc.ox.ac.uk}
• 关键词：chromatin binding ; multivalency ; structural rigidity ; plasticity ; histone marks ; masking of chromatin binding ; DNA damage ; protein network assembly
• 刊名：Cell Reports
• 出版年：2016
• 出版时间：6 December 2016
• 年：2016
• 卷：17
• 期：10
• 页码：2724-2737
• 全文大小：9540 K
• 卷排序：17

文摘

The ZMYND8 PHD/BRD/PWW cassette forms a stable structural reader ensemble The reader ensemble binds chromatin via simultaneous engagement of histones and DNA Each module of the ZMYND8 reader ensemble contributes to chromatin interactions Genome-wide distribution of ZMYND8 at enhancers is mediated by K14ac interactions