Prevalence and Associations of the Use of Proton-Pump Inhibitors in Nursing Homes: A Cross-Sectional Study

详细信息    查看全文

• 作者：Philipe de Souto Barreto ; PhD^a ; ^b ; ^{philipebarreto81@yahoo.com.br} ; Maryse Lapeyre-Mestre ; PhD^c ; ^d ; Cé ; line Mathieu ; MSc^e ; Christine Piau ; MD^f ; Catherine Bouget ; PhD^f ; Franç ; oise Cayla ; MD^e ; Bruno Vellas ; MD ; PhD^a ; ^c ; Yves Rolland ; MD ; PhD^a ; ^c
• 关键词：Acid-suppressive drugs ; older adults ; institutional setting ; elderly
• 刊名：Journal of the American Medical Directors Association
• 出版年：2013
• 出版时间：April, 2013
• 年：2013
• 卷：14
• 期：4
• 页码：265-269
• 全文大小：139 K

文摘

Objectives

Very scarce information is available about the use of proton-pump inhibitors (PPI) in nursing homes (NH). This study investigated the factors associated with PPI use among NH residents.

Design

Cross-sectional

Setting

One hundred seventy-five NHs in Midi-Pyr¨¦n¨¦es region, South-Western France.

Participants

Data was collected for 6275 NH residents. Participants (73.7 % women) were aged 86 years (¡À8.2).

Measurements

NH staff sent participants¡¯ drug prescriptions to research team; they also recorded information on residents¡¯ health characteristics. A binary logistic regression was performed on PPI use.

Results

PPI use was highly prevalent (n?= 2 370, ie, 37.8 % ). Whilst peptic ulcer (OR 4.741; 95 % CI 3.647-6.163) and nonsteroidal anti-inflammatory drugs (OR 2.124; 95 % CI 1.528-2.951) were important indicators of PPI use, they explained just a small fraction of PPI prescriptions; most prescriptions were probably inappropriately related to a general condition of health vulnerability, reflected by polypharmacy and comorbidities.

Conclusions

Vulnerable people take PPIs more often in NHs. Physicians must be aware about the health risks possibly induced by inappropriate PPI use when prescribing these drugs for NH residents.