Targeting Tumor-Associated Macrophages with Anti-CSF-1R Antibody Reveals a Strategy for Cancer Therapy
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- 作者：Carola H. Ries1 ; 13 ; carola.ries@roche.com" class="auth_mail ; Michael A. Cannarile1 ; 13 ; Sabine Hoves1 ; Jö ; rg Benz2 ; Katharina Wartha1 ; Valeria Runza1 ; Flora Rey-Giraud1 ; Leon P. Pradel1 ; Friedrich Feuerhake3 ; Irina Klaman1 ; Tobin Jones1 ; Ute Jucknischke1 ; Stefan Scheiblich1 ; Klaus Kaluza1 ; Ingo H. Gorr1 ; Antje Walz4 ; Keelara Abiraj4 ; Philippe A. Cassier5 ; Antonio Sica6 ; 7 ; Carlos Gomez-Roca8 ; Karin E. de Visser9 ; Antoine Italiano10 ; Christophe Le Tourneau11 ; Jean-Pierre Delord8 ; Hyam Levitsky12 ; Jean-Yves Blay5 ; Dominik Rü ; ttinger1
- 刊名：Cancer Cell
- 出版年：16 June 2014
- 年：2014
- 卷：25
- 期：6
- 页码：846-859
- 全文大小：4756 K
文摘
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Tumor-associated macrophages promote tumor progression
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Anti-CSF-1R antibody depletes tumor-associated macrophages in cancer patients
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CSF-1R inhibitor shows clinical activity in diffuse-type giant cell tumor patients
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CSF-1R signaling inhibition increases lymphocyte infiltration in cancer patients