- 作者：Patrice Cacoub ; Philippe Halfon ; Eric Rosenthal ; Franç ; ois Bailly ; Firouze Bani Sadr ; Yves Benhamou ; Sté ; phane Chevaliez ; Jean Michel Pawlotsky ; Lionel Piroth ; Yazdan Yazdanpanah ; Stanislas Po
- 关键词：HIV ; HCV ; Coinfection ; Treatment ; Interferon
- 刊名：Journal of Hepatology
- 出版年：2010
- 出版时间：August 2010
- 年：2010
- 卷：53
- 期：2
- 页码：230-237
- 全文大小：465 K
Background & Aims
To analyze the care of HCV infection in HIV–HCV coinfected patients and its progression between 2004 and 2009.Methods
Three hundred eighty HIV–HCV coinfected patients were prospectively included from November 22 to 29, 2004 (2004 survey), 416 patients from April 3 to 10, 2006 (2006 survey), and 419 patients from June 15 to 22, 2009 (2009 survey).
Results
The rate of liver biopsy decreased (14 % vs. 38 % vs. 56 % ), while the use of non-invasive liver damage tests increased (47 % vs. 24 % vs. ND) in the 2009, 2006, and 2004 surveys, respectively. The rate of patients that had never been treated for HCV infection progressively decreased in the 2009, 2006, and 2004 surveys (37 % , 42 % , and 54 % ). The main reasons for HCV non-treatment changed as HCV treatment was deemed less questionable and the lack of liver biopsy became a very rare reason (6 % , 18 % , and 34 % ). Among patients treated for HCV infection, the rate of sustained virological response increased (49 % , 29 % , and 29 % ). The main factors independently associated with HCV treatment were a liver fibrosis score F2 (odds ratio = 3.5; 95 % CI 2.1–5.7), a liver biopsy activity grade A2 (2.7; 1.4–5.3), a CD4 cell count 350 ml (2.7; 1.6–4.4), European origin (2.1; 1.3–3.4), daily alcohol consumption < 30 g (2.1; 1.2–3.8), and male gender (2.0; 1.2–3.3).
Conclusion
Compared to the 2004 and 2006 surveys, the 2009 coinfected patients had liver damage assessment more frequently, more patients had received HCV treatment and more patients had achieved a sustained virological response.