Structural and Mechanistic Paradigm of Leptin Receptor Activation Revealed by Complexes with Wild-Type and Antagonist Leptins
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- 作者：Kedar Moharana1 ; Lennart Zabeau2 ; Frank Peelman2 ; Philippe Ringler3 ; Henning Stahlberg3 ; Jan Tavernier2 ; jan.tavernier@vib-ugent.be" class="auth_mail ; Savvas N. Savvides1 ; savvas.savvides@ugent.be" class="auth_mail
- 刊名：Structure
- 出版年：10 June 2014
- 年：2014
- 卷：22
- 期：6
- 页码：866-877
- 全文大小：2801 K
文摘
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Structural insights into the assembly cornerstone of the leptin-LR signaling complex
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Leptin-based antagonists stall LR to binary complexes
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Inclusion of N-linked glycans drastically improves fitting of models to SAXS data
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Mechanistic proposal for the assembly of leptin-LR complexes at the cell surface