The role of autonomic efferents and uncoupling protein 1 in the glucose-lowering effect of leptin therapy
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- 作者：Heather C. Denroche1 ; Michelle M. Kwon1 ; Maria M. Glavas1 ; Eva Tudurí ; 1 ; Marion Philippe1 ; Whitney L. Quong1 ; Timothy J. Kieffer1 ; 2 ; tim.kieffer@ubc.ca" class="auth_mail" title="E-mail the corresponding author
- 关键词：Type 1 diabetes ; Glucose ; Vagotomy ; Sympathectomy ; Brown adipose tissue ; Streptozotocin
- 刊名：Molecular Metabolism
- 出版年：2016
- 出版时间：August 2016
- 年：2016
- 卷：5
- 期：8
- 页码：716-724
- 全文大小：822 K
文摘
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Leptin does not require vagal innervation to reverse hyperglycemia.
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Leptin therapy reverses hyperglycemia in mice with a partial chemical sympathectomy.
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Leptin reverses hyperglycemia independent of uncoupling protein 1.