Local landmark-based registration for fMRI group studies of nonprimary auditory cortex

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• 作者：Dragana Viceic ; Ruth Campos ; Eleonora Fornari ; Lucas Spierer ; Reto Meuli ; Stephanie Clarke ; Jean-Philippe Thiran
• 关键词：Auditory cortex ; Averaging ; fMRI ; Registration ; Sound recognition ; Sound localization
• 刊名：NeuroImage
• 出版年：2009
• 出版时间：1 January 2009
• 年：2009
• 卷：44
• 期：1
• 页码：145-153
• 全文大小：1436 K

文摘

Interindividual functional and structural brain variability is a major problem in group studies, in which very focal activations are expected. Architectonic studies have shown that the human primary auditory area, which is located with a great constancy on Heschl's gyrus, is surrounded by several nonprimary auditory areas with surface areas of 40–310 mm². The small size of the latter makes them only partially accessible to fMRI group studies, because of imprecision in realignment when using currently available registration procedures. We describe here a new method for sulcal realignment using a non-rigid local landmark-based registration and show its application to the registration of fMRI acquisitions on the supratemporal plane. After an affine global voxel-based registration, which transforms all brains into the same standard space, we propose a non-rigid local landmark-based registration method based on thin-plate splines for matching the two sulci delimiting Heschl's gyrus of a given brain to the corresponding sulci of a reference brain. We show here that, in comparison with global affine and non-rigid approaches, our method leads in group studies to i) a much more precise alignment of Heschl's gyrus; and ii) a putatively optimal superposition of functionally corresponding areas on and around Heschl's gyrus.